IVD reagent Material Tumor maker

Cancer antigen 125 (CA125) is a peptide epitope on the mucin glycoprotein MUC16. CA125 is the most widely used serum biomarker to monitor epithelial ovarian cancer. It is also used for the differential diagnosis of pelvic masses

Cancer antigen 15-3 (CA15-3) is identified through the use of two monoclonal antibodies, one specific for the MUC-1 protein core and another specific for a carbohydrate epitope on the MUC-1 protein. CA15-3 is a widely used serum marker for breast cancer monitoring. Antibodies 4401, 4402, 4403, and 4404 recognize the MUC-1 core protein of CA15-3.

Carbohydrate antigen 19-9 (CA19-9) is a tumor biomarker also called Sialyl Lewis A. Serum level measurements of CA19-9 are widely used in pancreatic cancer patients for monitoring their response to cancer treatments.

Carcinoembryonic antigen (CEA) is normally produced during fetal development. It has been used as a tumor marker for colorectal cancer and several carcinomas.

Alpha-fetoprotein (AFP) is a major plasma protein produced by the fetus. AFP is measured in pregnancy as a screening test for a subset of developmental abnormalities. It is also used as a biomarker to detect a subset of tumors.

Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues.

β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.

Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses. EBV is found all over the world. Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses.

 CYFRA 21-1 is a fragment of cytokeratin 19 that is typically associated with epithelial cell cancers, including NSCLC, and is typically associated with the SQLC type. Since cytokeratins are structural proteins of keratin-containing intermediate filaments found in the epithelial cells, their degradation produces soluble fragments which are measurable in the blood of lung cancer patients as a tumor marker